SS-31

SS-31 (also known as Elamipretide, MTP-131, Bendavia, Szeto-Schiller-31) is a mitochondria-targeted tetrapeptide widely used in laboratory studies of mitochondrial membranes and cardiolipin interactions. Synonyms: SS-31 · Elamipretide · MTP-131 · Bendavia · Szeto-Schiller-31 Chemical Specifications: • Sequence: D-Arg–Dmt–Lys–Phe–NH₂ (one-letter: dR–{Dmt}–K–F–NH₂) • Molecular Formula: C₃₂H₄₉N₉O₅ • Molecular Weight: ~639.8 g/mol • CAS (free base): 736992-21-5 • Form: Lyophilized powder • Purity: ≥ 98% (HPLC), lot-specific COA • Identity: Confirmed by MS/peptide mapping (per lot COA) • Solubility: Water or appropriate aqueous buffers • Appearance: White to off-white powder Research Focus: • Mitochondrial membrane integrity • Cardiolipin binding and stabilization • Oxidative stress protection in cellular models • Mitochondrial bioenergetics • Cardiac and renal ischemia-reperfusion research models Storage & Handling: Store at −20 °C long-term; protect from light and moisture. For short-term use, keep sealed vials at 2–8 °C. Allow vial to reach room temperature before opening to minimize condensation. Reconstitute under aseptic conditions; avoid repeated freeze–thaw—aliquot after reconstitution. For in-vitro laboratory research only. Not a drug, food, or cosmetic. Not for human or veterinary use, clinical applications, or household use.